منابع مشابه
B cells in autoimmunity
B-cell development is tightly regulated, including the induction of B-cell memory and antibody-secreting plasmablasts and plasma cells. In the last decade, we have expanded our understanding of effector functions of B cells as well as their roles in human autoimmune diseases. The current review addresses the role of certain stages of B-cell development as well as plasmablasts/plasma cells in im...
متن کاملAutoimmunity: Deletion of autoreactive B cells
Several powerful mechanisms exist to prevent self-reactive B cells from maturing to secrete potentially destructive autoantibodies. These mechanisms act in addition to the removal of self-reactive helper T cells.
متن کاملB-cell tolerance and autoimmunity
Self-reactive B cells are tolerized at various stages of B-cell development and differentiation, including the immature B-cell stage (central tolerance) and the germinal center (GC) B-cell stage, and B-cell tolerance involves various mechanisms such as deletion, anergy, and receptor editing. Self-reactive B cells generated by random immunoglobulin variable gene rearrangements are tolerized by c...
متن کاملTLR-activated B cells suppress T cell-mediated autoimmunity.
TLR sense microbial infections, and control activation of immune responses. Dendritic cells, macrophages, and B lymphocytes express TLR and the TLR-signaling adaptor protein MyD88. The impact of TLR-activated B cells on T cell-mediated inflammation is unknown. In this study, we have used mice carrying B cell-restricted deficiencies in MyD88 or in distinct TLR to examine the impact of TLR-activa...
متن کاملThe Role of Latently Infected B Cells in CNS Autoimmunity
The onset of multiple sclerosis (MS) is caused by both genetic and environmental factors. Among the environmental factors, it is believed that previous infection with Epstein-Barr virus (EBV) may contribute in the development of MS. EBV has been associated with other autoimmune diseases, such as systemic lupus erythematous, and cancers like Burkitt's lymphoma. EBV establishes a life-long latenc...
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ژورنال
عنوان ژورنال: Current Opinion in Immunology
سال: 2011
ISSN: 0952-7915
DOI: 10.1016/j.coi.2011.10.007